What Are Collagen Biostimulators And What Do They Do

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Collagen biostimulators represent a significant advancement in aesthetic medicine, offering a non-surgical approach to skin rejuvenation. As we age, our skin’s natural collagen production diminishes, leading to wrinkles, sagging, and a loss of firmness. Collagen biostimulators address these concerns by encouraging the body’s own collagen production, resulting in a more youthful and revitalised appearance.

Introduction to Collagen Biostimulators

Collagen biostimulator treatments are minimally invasive procedures that enhance the body’s natural collagen production. Substances like poly-L-lactic acid (PLLA) or calcium hydroxyapatite are injected into the deep dermis to rejuvenate the skin’s structure and volume. The treatment works by stimulating fibroblasts, the cells responsible for collagen production. 


Collagen Biostimulators

This process not only augments current collagen levels but also helps reduce future collagen degradation. It’s suitable for individuals with skin concerns and realistic expectations. Typically applied to the face, neck, décolletage, and hands, the results develop over weeks or months and can last up to two years. The number of treatments varies based on individual needs, and side effects are usually mild and temporary. Collagen biostimulators differ from bio-remodelling injections, with the former focusing on gradual collagen renewal.

Benefits of Collagen Biostimulators on Skin


The benefits of collagen biostimulators are rooted in their ability to enhance the skin’s natural regenerative capabilities. Key advantages include:

  1. Enhancement of Skin Elasticity: By boosting collagen production, these treatments improve the skin’s elasticity, helping to reduce the appearance of sagging and wrinkles.
  1. Improvement in Skin Texture: Patients often observe a more even skin texture, with a noticeable reduction in the appearance of fine lines and pores.
  1. Restoration of Facial Volume: Collagen biostimulators can help replenish lost facial volume in a natural-looking way, counteracting the hollow or sunken appearance often associated with ageing.
  1. Long-Lasting Results: The effects of collagen biostimulators are not immediate but develop over time, offering long-lasting improvements in skin quality.
  1. Preventative Anti-Ageing Effects: These treatments can also be used proactively to slow down the ageing process, helping to maintain a youthful complexion.
  1. Minimal Downtime: Typically, these procedures involve minimal downtime, allowing patients to return to their daily activities shortly after treatment.

It’s important to note that individual results from collagen biostimulator treatments can vary. Therefore, a consultation with a qualified medical professional is essential to determine the appropriateness and expected outcomes of the treatment. 

For those seeking more detailed information and personalised advice, NU•U Aesthetics & Wellness Clinic offers professional consultations. They can provide insights tailored to individual needs and expectations, ensuring an informed decision-making process.

Types of Collagen Biostimulators Accessible in Singapore

In Singapore, several types of collagen biostimulators are available, each with unique properties and applications. Here’s a brief overview:

Sculptra PLLA Collagen Biostimulator

Sculptra is a collagen-boosting treatment renowned for its main ingredient, poly-L-lactic acid (PLLA). It is engineered to work beneath the skin’s surface, where it gradually promotes the production of collagen. This makes it particularly effective for treating deep facial wrinkles, folds, and replenishing lost facial volume due to ageing. The results of Sculptra aren’t immediate; they unfold over time and can last up to two years.

The US FDA first approved Sculptra in 2004, recognising its ability to boost collagen production in cases related to lipoatrophy. A notable development occurred in December 2021, when Galderma announced that Sculptra had been designated as the first and only FDA-approved PLLA facial injectable for stimulating the skin’s own collagen production. This breakthrough marked Sculptra as a distinct option for smoothing facial wrinkles, including smile lines.

Sculptra is widely acclaimed for producing results that look natural and last a long time. This characteristic of Sculptra makes it an option for individuals seeking subtle yet effective solutions for ageing signs.


Radiesse is another collagen biostimulator, distinguished by its composition of Calcium Hydroxylapatite (CaHA) microspheres suspended in a gel carrier. It not only provides immediate volume correction but also stimulates the production of natural collagen. Radiesse is often used for smoothing moderate to severe facial wrinkles and folds, such as nasolabial folds. Over time, the gel is absorbed and the body metabolises the CaHA microspheres, leaving behind your own and increased natural collagen.


GOURI, a relatively newer addition to the field of collagen biostimulators, is formulated with liquid polycaprolactone (PCL). It is known for its long-lasting skin rejuvenation effects, working to enhance skin elasticity and reduce signs of ageing like fine lines and sagging. The liquid PCL is biodegradable and biocompatible, integrating well with the skin’s natural structure and promoting the production of new collagen over an extended period.


Aesthefill stands out due to its primary component, PDLLA (poly-D-L-lactic acid), which acts as a powerful stimulator for collagen production. It is designed to provide gradual improvements in skin texture and volume, making it suitable for those looking for subtle, yet effective anti-ageing treatments. Aesthefill is commonly used for facial contouring and reducing the appearance of wrinkles, with results that improve over time as the skin generates more collagen.


Ellanse is a versatile dermal filler designed to offer both immediate volume enhancement and prolonged collagen stimulation. The filler’s composition, featuring polycaprolactone microspheres encapsulated in a gel carrier, is injected directly into the skin. This unique formulation not only delivers instant volumising benefits but also gradually promotes the body’s natural production of collagen. Suitable for application in a variety of areas, including the face and hands, Ellanse effectively targets concerns such as wrinkles, loss of volume, and skin laxity. 

The results of this treatment can last from 18 months to as long as 2 years, with the benefits becoming progressively more apparent as collagen synthesis in the body increases. Typically, the Ellanse procedure is completed in a single session, and various anaesthetic options are available to ensure patient comfort. It is essential to consult with a healthcare professional before undergoing treatment with Ellanse, both to determine its suitability for your specific needs and to understand any potential risks involved.

Each of these collagen biostimulators has its specific applications and suitability, depending on individual skin types and desired outcomes. A thorough consultation with a qualified practitioner is recommended to determine the best choice for one’s unique skin needs.

What to Expect During the Treatment?

In a collagen biostimulator treatment, a thorough initial consultation assesses skin condition and treatment goals. The procedure itself is minimally invasive, involving the precise injection of the biostimulator, like PLLA or calcium hydroxyapatite, into targeted skin areas. This stimulates the deeper layers of skin to renew collagen production. While undergoing treatment, patients might feel mild discomfort, typically managed with topical anaesthetics. Post-treatment, there may be temporary redness or swelling. The full effects develop gradually over several months as collagen production increases.

Selecting a Suitable Collagen Biostimulator Treatment

Selecting the right collagen biostimulators

The selection of an appropriate collagen biostimulator involves a detailed evaluation of individual factors. Skin type, for instance, determines the treatment’s responsiveness; sensitive skin may require a gentler biostimulator. Age-related concerns like deep wrinkles or volume loss guide the choice between biostimulators like Sculptra, which targets deeper layers, versus Aesthefill, suited for more superficial application. 

A practitioner assesses these aspects and reviews treatment histories, such as a patient’s response to previous collagen stimulators, to advise on the most compatible option. Awareness of potential side effects, like temporary redness or swelling, is also integral to this decision-making process.


Collagen biostimulators, including options like Sculptra, Radiesse, GOURI, Ellanse, and Aesthefill, provide a method for skin rejuvenation, tailored to various individual needs. These treatments, each with distinct characteristics, support the skin’s natural collagen production process. The importance of a professional consultation cannot be overstated; it ensures a tailored approach to treatment selection and addresses safety and efficacy concerns. Consulting with an aesthetic doctor is a critical step in exploring these treatments and working towards specific aesthetic objectives.

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