Polynucleotides For Anti-Ageing – What You Need To Know About This Regenerative Treatment

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Polynucleotide therapy is a modern approach to anti-ageing in aesthetic medicine. This treatment, gaining recognition for its effectiveness, uses the natural regenerative properties of polynucleotides to improve skin health. This article provides an overview of what polynucleotides are and their benefits for skin rejuvenation and anti-ageing.

What Are Polynucleotides?

Polynucleotides are biological molecules that form the foundation of our genetic material. They are long chains of nucleotides, which are the building blocks of DNA and RNA. These molecules play a vital role in the body, particularly in cell repair and the transmission of genetic information.

Polynucleotides are derived from natural sources, such as the DNA of salmon. They undergo a rigorous purification process and are then used for their remarkable skin rejuvenation properties. By improving cellular function and promoting skin repair, polynucleotides have become an invaluable tool in aesthetic treatments.

They are particularly effective in stimulating the production of collagen and elastin. These proteins are essential for maintaining skin elasticity and firmness, which tend to decrease with age. By activating fibroblasts, the cells responsible for producing collagen and elastin, polynucleotides help to rejuvenate the skin and improve various conditions. The treatment involves micro-injections directly into the skin, delivering these potent molecules where they can have the most impact.

What Are The Benefits Of Polynucleotides On Skin?

Addressing Signs of Ageing

One of the key benefits of polynucleotide therapy is its ability to counteract signs of ageing. The treatment stimulates fibroblasts, cells crucial for producing collagen and elastin. Collagen and elastin are proteins that give skin its firmness and elasticity, which naturally diminish with age. By enhancing the production of these proteins, polynucleotide injections can reduce the appearance of fine lines and wrinkles, leading to smoother and more youthful-looking skin.

Scar Reduction

Polynucleotide therapy is also beneficial in reducing the appearance of scars. This includes scars from acne, surgery, or trauma. The treatment works by promoting the regeneration of skin cells and improving the skin’s repair mechanisms. This process not only accelerates the healing of new scars but can also make older scars less noticeable, leading to an improved skin texture and appearance.

Hydration Boost

Hydration is vital for maintaining healthy, resilient skin. Polynucleotide treatments can enhance the skin’s ability to retain moisture by stimulating the production of hyaluronic acid. Hyaluronic acid is a naturally occurring substance in the skin that retains water, ensuring the skin remains hydrated and plump. This benefit is particularly noticeable in areas of the skin that tend to dry out or appear dull due to dehydration.

Prevent Cell Damage

Another significant advantage of polynucleotide treatments is their protective effect against cellular damage. Environmental factors, such as UV radiation, can cause damage to the skin cells’ DNA, leading to premature ageing and other skin issues. Polynucleotides contribute to the repair and maintenance of DNA within these cells, enhancing their resilience and ability to function correctly. This protective mechanism helps maintain healthy, vibrant skin.

What is the Polynucleotide Treatment Like?

Procedure & Area Of Treatment

Polynucleotide treatment is a minimally invasive procedure that can be applied to various areas, particularly those showing signs of ageing or damage, such as the face, neck, hands, and even the scalp. The process utilises very fine needles, tailored to ensure precision and minimise discomfort.

The procedure can be performed with or without a topical anaesthetic. The use of anaesthetic depends on the patient’s comfort level and the area being treated. Despite being a needle-based procedure, it typically causes minimal discomfort. The entire process is relatively quick, often completed within 30 to 60 minutes, depending on the treatment’s extent and the areas covered.

What Results Can You See From The Treatment?

After undergoing a polynucleotide treatment, patients can typically expect to see several types of improvements in their skin, which become more noticeable over time. These improvements include:

  • Better skin firmness and elasticity, which is a result of increased collagen production. Collagen is a protein that maintains the skin’s firmness and a youthful look.
  • Enhanced healing of the skin, especially beneficial for skin that is damaged or showing signs of ageing.
  • A decrease in the appearance of ageing signs, leading to a fresher and younger look.
  • More hydrated skin, giving it a healthier and more vibrant tone.

While some early signs of improvement might be visible within a few weeks, usually within 2-3 weeks, the complete results of the treatment are generally seen after about three months.

What Are Some Potential Side Effects Of A Polynucleotide Treatment?

While polynucleotide treatments for anti-ageing are generally considered safe, there are potential side effects that patients should be aware of. These include:

  • Persistent pain, swelling, or inflammation: Some individuals may experience prolonged pain, swelling, or inflammation at the injection sites. This discomfort is typically temporary but can last longer than the usual minor reactions.
  • Infection: Though it is rare, there is a slight risk of infection following the treatment. This risk is similar to that associated with other types of skin injections.
  • Redness, swelling, or bruising: It is common to have redness, swelling, or bruising at the injection sites. These symptoms are usually mild and tend to subside within a few days.
  • Skin damage and scarring: In rare cases, more serious side effects such as skin damage and scarring can occur. However, these are not common and are usually associated with incorrect application of the treatment.

It is crucial to have a thorough discussion about potential risks and side effects with a qualified practitioner before undergoing the treatment. If any adverse effects occur, it’s important to seek advice from your healthcare provider. Always ensure that the practitioner performing the treatment is experienced and qualified, as this can significantly reduce the risk of serious side effects.

How Long Does It Take To See Results?

The results from polynucleotide treatments vary from person to person. Typically, initial improvements might be noticeable within 2-3 weeks after the treatment. However, the full impact of the treatment usually becomes evident after about three months. This delay is because the polynucleotides work at a cellular level, stimulating processes like collagen production and skin repair, which take time to manifest visibly.

How Often Should One Receive The Treatment?

The frequency of polynucleotide treatments depends on individual skin conditions and the desired outcomes. Generally, a series of treatments is recommended for optimal results. Initially, a course of four sessions, spaced about four weeks apart, is often advised. After completing this initial series, maintenance treatments every 6-12 months can help sustain the benefits. It’s important to consult with a healthcare professional to determine a treatment plan tailored to your specific needs and skin goals.


Polynucleotide treatments represent an advanced approach in the field of anti-ageing and skin rejuvenation. While individual results may vary, many users experience improvements in skin elasticity, hydration, and overall appearance. This procedure is minimally invasive and generally safe, though it’s important to be aware of potential side effects. Consulting with a qualified practitioner is crucial to tailor the treatment to your specific needs and ensure its safe and effective execution. Clinics like NU•U Aesthetics & Wellness exemplify the importance of personalised care in aesthetic treatments. They offer a range of procedures, each designed to meet different skin concerns and backed by professional advice.

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